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1

Voices of biotech

Amit, Ido, Baker, David, Barker, Roger, Berger, Bonnie, Bertozzi, Carolyn, Bhatia, Sangeeta, Biffi, Alessandra, Demichelis, Francesca, Doudna, Jennifer, Dowdy, Steven F, Endy, Drew, Helmstaedter, Mori

Journal:

Nature Biotechnology

Year:

2016

Language:

english

File:

PDF, 3.22 MB

english, 2016

2

Discussions on The Receiving System for Long-Wave Transatlantic Radio Telegraphy (Austin Bailey, S. W. Dean, and W. T. Wintringham)

Biffi, Emilia, Piraino, Francesco, Pedrocchi, Alessandra, Fiore, Gianfranco B., Ferrigno, Giancarlo, Redaelli, Alberto, Menegon, Andrea, Rasponi, Marco

Journal:

Proceedings of the IRE

Year:

1929

Language:

english

File:

PDF, 1.23 MB

english, 1929

3

Effects of dose and duration of robot-assisted gait training on walking ability of children affected by cerebral palsy

Peri, Elisabetta, Turconi, Anna Carla, Biffi, Emilia, Maghini, Cristina, Panzeri, Daniele, Morganti, Roberta, Pedrocchi, Alessandra, Gagliardi, Chiara

Journal:

Technology and Health Care

Year:

2017

Language:

english

File:

PDF, 388 KB

english, 2017

4

Microglial dysfunction as a key pathologic change in adrenomyeloneuropathy

Gong, Yi, Sasidharan, Nikhil, Laheji, Fiza, Frosch, Matthew, Musolino, Patricia, Tanzi, Rudy, Kim, Doo Yeon, Biffi, Alessandra, El Khoury, Joseph, Eichler, Florian

Journal:

Annals of Neurology

Year:

2017

Language:

english

File:

PDF, 2.40 MB

english, 2017

5

Pre-clinical safety and efficacy evaluation of GMP lentiviral vector in preparation for a clinical trial of hematopoietic stem cell gene therapy in MPS IIIA

Ellison, Stuart M., Wood, Shaun, Sergijenko, Ana, Armant, Myriam, Chan, Lucas, Farzaneh, Farzin, Jones, Simon, Wynn, Rob, Gaspar, Bobby, Biffi, Alessandra, Bigger, Brian

Journal:

Molecular Genetics and Metabolism

Year:

2018

Language:

english

File:

PDF, 56 KB

english, 2018

6

Effect of robotic-assisted gait training in a large population of children with motor impairment due to cerebral palsy or acquired brain injury

Beretta, Elena, Storm, Fabio Alexander, Strazzer, Sandra, Frascarelli, Flaminia, Petrarca, Maurizio, Colazza, Alessandra, Cordone, Giampietro, Biffi, Emilia, Morganti, Roberta, Maghini, Cristina, Picc

Journal:

Archives of Physical Medicine and Rehabilitation

Year:

2019

File:

PDF, 2.22 MB

2019

7

Pediatric Patients Treated for Leukemia Back to School: A Mixed-Method Analysis of Narratives about Daily Life and Illness Experience

Tremolada, Marta, Taverna, Livia, Bonichini, Sabrina, Pillon, Marta, Biffi, Alessandra, Putti, Maria Caterina

Journal:

Behavioral Sciences

Year:

2020

File:

PDF, 424 KB

2020

8

Cationic Carboxylato Complexes of Dirhodium(II) with Oxo Thioethers: Catalysts for Silane Alcoholysis under Homogeneous and Liquid-Liquid Biphasic Conditions

Andrea Biffis, Marino Basato, Marianna Brichese, Luca Ronconi, Cristina Tubaro, Alessandra Zanella, Claudia Graiff, Antonio Tiripicchio

Journal:

Advanced Synthesis & Catalysis

Year:

2007

Language:

english

File:

PDF, 226 KB

english, 2007

9

Validation of long-term primary neuronal cultures and network activity through the integration of reversibly bonded microbioreactors and MEA substrates

Emilia Biffi, Andrea Menegon, Francesco Piraino, Alessandra Pedrocchi, Gianfranco B. Fiore, Marco Rasponi

Journal:

Biotechnology and Bioengineering

Year:

2012

Language:

english

File:

PDF, 507 KB

english, 2012

10

Development and maturation of invariant NKT cells in the presence of lysosomal engulfment

Tiziana Plati, Ilaria Visigalli, Alessia Capotondo, Mario Buono, Luigi Naldini, Maria Pia Cosma, Alessandra Biffi

Journal:

European Journal of Immunology

Year:

2009

Language:

english

File:

PDF, 325 KB

english, 2009

11

Characterization of new arylsulfatase A gene mutations reinforces genotype-phenotype correlation in metachromatic leukodystrophy

Martina Cesani, Alessia Capotondo, Tiziana Plati, Lucia Sergi Sergi, Francesca Fumagalli, Maria Grazia Roncarolo, Luigi Naldini, Giancarlo Comi, Maria Sessa, Alessandra Biffi

Journal:

Year:

2009

Language:

english

File:

PDF, 186 KB

english, 2009

12

High incidence of severe cyclosporine neurotoxicity in children affected by haemoglobinopaties undergoing myeloablative haematopoietic stem cell transplantation: early diagnosis and prompt intervention ameliorates neurological outcome

Anna Noè, Barbara Cappelli, Alessandra Biffi, Robert Chiesa, Ilaria Frugnoli, Erika Biral, Valentina Finizio, Cristina Baldoli, Paolo Vezzulli, Fabio Minicucci, Giovanna Fanelli, Rossana Fiori, Fabio

Journal:

Italian Journal of Pediatrics

Year:

2010

Language:

english

File:

PDF, 1.26 MB

english, 2010

13

Absence of VOD in paediatric thalassaemic HSCT recipients using defibrotide prophylaxis and intravenous Busulphan

Barbara Cappelli, Robert Chiesa, Costanza Evangelio, Alessandra Biffi, Tito Roccia, Ilaria Frugnoli, Erika Biral, Anna Noè, Marco Fossati, Valentina Finizio, Roberto Miniero, Sara Napolitano, Francesc

Journal:

British Journal of Haematology

Year:

2009

Language:

english

File:

PDF, 89 KB

english, 2009

14

Coordinate dual-gene transgenesis by lentiviral vectors carrying synthetic bidirectional promoters

Amendola, Mario, Venneri, Mary Anna, Biffi, Alessandra, Vigna, Elisa, Naldini, Luigi

Journal:

Nature Biotechnology

Year:

2004

Language:

english

File:

PDF, 514 KB

english, 2004

15

Characteristics of ventricular tachyarrhythmias occurring in ischemic versus nonischemic patients implanted with a biventricular cardioverter-defibrillator for primary or secondary prevention of sudden death

Giuseppe Boriani, Maurizio Gasparini, Maurizio Lunati, Massimo Santini, Maurizio Landolina, Antonio Vincenti, Antonio Curnis, Mario Bocchiardo, Luigi Padeletti, Mauro Biffi, Luca Allaria, Alessandra D

Journal:

American Heart Journal

Year:

2006

Language:

english

File:

PDF, 399 KB

english, 2006

16

Impaired striatal GABA transmission in experimental autoimmune encephalomyelitis

Silvia Rossi, Luca Muzio, Valentina De Chiara, Giorgio Grasselli, Alessandra Musella, Gabriele Musumeci, Georgia Mandolesi, Roberta De Ceglia, Simona Maida, Emilia Biffi, Alessandra Pedrocchi, Andrea

Journal:

Brain, Behavior, and Immunity

Year:

2011

Language:

english

File:

PDF, 1.37 MB

english, 2011

17

Unpredictability of Intravenous Busulfan Pharmacokinetics in Children Undergoing Hematopoietic Stem Cell Transplantation for Advanced Beta Thalassemia: Limited Toxicity with a Dose-Adjustment Policy

Robert Chiesa, Barbara Cappelli, Roberto Crocchiolo, Ilaria Frugnoli, Erika Biral, Anna Noè, Costanza Evangelio, Marco Fossati, Tito Roccia, Alessandra Biffi, Valentina Finizio, Alessandro Aiuti, Moni

Journal:

Biology of Blood and Marrow Transplantation

Year:

2010

Language:

english

File:

PDF, 310 KB

english, 2010

18

The deep-water counterpart of the Messinian Lower Evaporites in the Apennine foredeep: The Fanantello section (Northern Apennines, Italy)

Vinicio Manzi, Marco Roveri, Rocco Gennari, Adele Bertini, Ulderico Biffi, Simona Giunta, Silvia Maria Iaccarino, Luca Lanci, Stefano Lugli, Alessandra Negri, Angelo Riva, Massimo Edoardo Rossi, Marco

Journal:

Palaeogeography, Palaeoclimatology, Palaeoecology

Year:

2007

Language:

english

File:

PDF, 4.77 MB

english, 2007

19

Somatic intragenic recombination of the arylsulfatase A gene in a metachromatic leukodystrophy patient

Stefano Regis, Susanna Lualdi, Alessandra Biffi, Maria Sessa, Fabio Corsolini, Giancarlo Parenti, Mirella Filocamo

Journal:

Molecular Genetics and Metabolism

Year:

2006

Language:

english

File:

PDF, 364 KB

english, 2006

20

15 Correction of established neurologic disease and evidences of in vivo cross correction in the mouse model of metachromatic leukodystrophy

Alessandra Biffi, Alessia Capotondo, Stefania Fasano, Ubaldo del Carro, Sergio Marchesini, Riccardo Brambilla, Marcus Grompe, Claudio Bordignon, Angelo Quattrini, Luigi Naldini

Journal:

Molecular Genetics and Metabolism

Year:

2007

Language:

english

File:

PDF, 54 KB

english, 2007

21

9. Hematopoietic stem cell based gene therapy for the treatment of metachromatic leukodystrophy: Towards clinical testing

Alessandra Biffi, Alessia Capotondo, Martina Cesani, Eugenio Montini, Tiziana Plati, Fabrizio Benedicenti, Laura Tononi, Sergio Marchesini, Maria Sessa, Claudio Bordignon, Maria Grazia Roncarolo, Luig

Journal:

Molecular Genetics and Metabolism

Year:

2008

Language:

english

File:

PDF, 43 KB

english, 2008

22

103. Development of an effective and safe hematopoietic stem cell gene therapy for globoid cell leukodystrophy: The unexpected issue of GALC toxicity

Ilaria Visigalli, Martina Cesani, Margherita Neri, Silvia Ungari, Laura Tononi, Sergio Marchesini, Manuel Grez, Angela Gritti, Luigi Naldini, Alessandra Biffi

Journal:

Molecular Genetics and Metabolism

Year:

2008

Language:

english

File:

PDF, 44 KB

english, 2008

23

Prevalence and Clinical Significance of Left Atrial Remodeling in Competitive Athletes

Antonio Pelliccia, Barry J. Maron, Fernando M. Di Paolo, Alessandro Biffi, Filippo M. Quattrini, Cataldo Pisicchio, Alessandra Roselli, Stefano Caselli, Franco Culasso

Journal:

Journal of the American College of Cardiology

Year:

2005

Language:

english

File:

PDF, 239 KB

english, 2005

24

A New Analytical Bench Assay for the Determination of Arylsulfatase A Activity Toward Galactosyl-3-Sulfate Ceramide: Implication for Metachromatic Leukodystrophy Diagnosis

Morena, Francesco, di Girolamo, Ilaria, Emiliani, Carla, Gritti, Angela, Biffi, Alessandra, Martino, Sabata

Journal:

Analytical Chemistry

Year:

2014

Language:

english

File:

PDF, 1.45 MB

english, 2014

25

Restoration of Bacterial Killing Activity of Human Respiratory Cystic Fibrosis Cells through Cationic Vector-Mediated Cystic Fibrosis Transmembrane Conductance Regulator Gene Transfer

Biffi, Alessandra, Sersale, Giovanna, Cassetti, Arianna, Villa, Antonello, Bordignon, Claudio, Assael, Baroukh M., Conese, Massimo

Journal:

Human Gene Therapy

Year:

1999

Language:

english

File:

PDF, 465 KB

english, 1999

26

Gene Therapy of Storage Disorders by Retroviral and Lentiviral Vectors

Biffi, Alessandra, Naldini, Luigi

Journal:

Human Gene Therapy

Year:

2005

Language:

english

File:

PDF, 100 KB

english, 2005

27

A microfluidic platform for controlled biochemical stimulation of twin neuronal networks

Biffi, Emilia, Piraino, Francesco, Pedrocchi, Alessandra, Fiore, Gianfranco B., Ferrigno, Giancarlo, Redaelli, Alberto, Menegon, Andrea, Rasponi, Marco

Journal:

Biomicrofluidics

Year:

2012

Language:

english

File:

PDF, 1.97 MB

english, 2012

28

Novel candidate disease for gene therapy: metachromatic leukodystrophy

Biffi, Alessandra, Naldini, Luigi

Journal:

Expert Opinion on Biological Therapy

Year:

2007

Language:

english

File:

PDF, 1.13 MB

english, 2007

29

408. Safety of Lysosomal Enzymes Over-Expression in HSC for Gene Therapy of Storage Disorders

Biffi, Alessandra, Visigalli, Ilaria, Cesani, Martina, Capotondo, Alessia, Santoni de Sio, Francesca R., Pallavicini, Isabella, Zingale, Anna, Naldini, Luigi

Journal:

Molecular Therapy

Year:

2006

Language:

english

File:

PDF, 82 KB

english, 2006

30

442. LV Expressing MR Reporter Genes Allows In Vivo Monitoring of Stem Cell Gene Therapy

Amendola, Mario, S. Politi, Letterio, Cadioli, Marcello, Galli, Rossella, Binda, Elena, Falini, Andrea, Levi, Sonia, Scotti, Giuseppe, Biffi, Alessandra, Naldini, Luigi

Journal:

Molecular Therapy

Year:

2006

Language:

english

File:

PDF, 83 KB

english, 2006

31

891. Correction of Established Neurologic Disease and Evidences of In Vivo Cross Correction in the Mouse Model of Metachromatic Leukodystrophy

Biffi, Alessandra, Capotondo, Alessia, Fasano, Stefania, del Carro, Ubaldo, Marchesini, Sergio, Azuma, Hisaya, Brambilla, Riccardo, Grompe, Markus, Bordignon, Claudio, Quattrini, Angelo, Naldini, Luig

Journal:

Molecular Therapy

Year:

2006

Language:

english

File:

PDF, 82 KB

english, 2006

32

888. Characterization of New Murine Models of Globoid Cell Leukodystrophy: Relevance for Gene Therapy Applications and Studies on Disease Pathogenesis

Visigalli, Ilaria, del Carro, Ubaldo, Politi, Letterio, Quattrini, Angelo, Luzi, Paola, Wenger, David, Naldini, Luigi, Biffi, Alessandra

Journal:

Molecular Therapy

Year:

2006

Language:

english

File:

PDF, 83 KB

english, 2006

33

864. Characterization of Transgenic Mice Over-Expressing Arylsulfatase A: Implications for Gene Therapy and Sulfatases Activation Mechanisms

Capotondo, Alessia, Venneri, Mary A., Cosma, Maria P., Pallavicini, Isabella, Ballabio, Andrea, Naldini, Luigi, Biffi, Alessandra

Journal:

Molecular Therapy

Year:

2006

Language:

english

File:

PDF, 99 KB

english, 2006

34

Clinical Translation of TALENS: Treating SCID-X1 by Gene Editing in iPSCs

Biffi, Alessandra

Journal:

Year:

2015

Language:

english

File:

PDF, 156 KB

english, 2015

35

Repolarization effects of multiple-cycle chemotherapy and predictors of QTc prolongation: a prospective female cohort study on >2000 ECGs

Diemberger, Igor, Massaro, Giulia, Cubelli, Marta, Rubino, Daniela, Quercia, Sara, Martignani, Cristian, Ziacchi, Matteo, Biffi, Mauro, Bernardi, Alessandra, Cacciari, Nicoletta, Zamagni, Claudio, Bor

Journal:

European Journal of Clinical Pharmacology

Year:

2015

Language:

english

File:

PDF, 631 KB

english, 2015

36

Hematopoietic stem cell transplantation for metachromatic leukodystrophy

Lorioli, Laura, Biffi, Alessandra

Journal:

Expert Opinion on Orphan Drugs

Year:

2015

Language:

english

File:

PDF, 200 KB

english, 2015

37

GENE THERAPY FOR lYSOSOMAL STORAGE DISORDERS: A GOOD START

Biffi, Alessandra

Journal:

Human Molecular Genetics

Year:

2015

Language:

english

File:

PDF, 1.04 MB

english, 2015

38

Pioglitazone as a novel therapeutic approach in chronic granulomatous disease

Migliavacca, Maddalena, Assanelli, Andrea, Ferrua, Francesca, Cicalese, Maria Pia, Biffi, Alessandra, Frittoli, Marta, Silvani, Paolo, Chidini, Giovanna, Calderini, Edoardo, Mandelli, Anna, Camporesi,

Journal:

Journal of Allergy and Clinical Immunology

Year:

2016

Language:

english

File:

PDF, 528 KB

english, 2016

39

Mutation Update of ARSA and PSAP Genes Causing Metachromatic Leukodystrophy

Cesani, Martina, Lorioli, Laura, Grossi, Serena, Amico, Giulia, Fumagalli, Francesca, Spiga, Ivana, Filocamo, Mirella, Biffi, Alessandra

Journal:

Year:

2016

Language:

english

File:

PDF, 953 KB

english, 2016

40

Mesoangioblast delivery of miniagrin ameliorates murine model of merosin-deficient congenital muscular dystrophy type 1A

Domi, Teuta, Porrello, Emanuela, Velardo, Daniele, Capotondo, Alessia, Biffi, Alessandra, Tonlorenzi, Rossana, Amadio, Stefano, Ambrosi, Alessandro, Miyagoe-Suzuki, Yuko, Takeda, Shin’ichi, Ruegg, Mar

Journal:

Skeletal Muscle

Year:

2015

Language:

english

File:

PDF, 2.32 MB

english, 2015

41

Genetically-Modified Hematopoietic Stem Cells and their Progeny for Widespread and Efficient Protein Delivery to Diseased Sites: The Case of Lysosomal Storage Disorders

Biffi, Alessandra

Journal:

Current Gene Therapy

Year:

2012

Language:

english

File:

PDF, 151 KB

english, 2012

42

Maintenance of a functional hematopoietic stem cell niche through galactocerebrosidase and other enzymes

Visigalli, Ilaria, Biffi, Alessandra

Journal:

Current Opinion in Hematology

Year:

2011

Language:

english

File:

PDF, 211 KB

english, 2011

43

Development of a bench-top device for parallel climate-controlled recordings of neuronal cultures activity with microelectrode arrays

Regalia, Giulia, Biffi, Emilia, Achilli, Silvia, Ferrigno, Giancarlo, Menegon, Andrea, Pedrocchi, Alessandra

Journal:

Biotechnology and Bioengineering

Year:

2016

Language:

english

File:

PDF, 2.92 MB

english, 2016

44

SUMF1 enhances sulfatase activities in vivo in five sulfatase deficiencies

Fraldi, Alessandro, Biffi, Alessandra, Lombardi, Alessia, Visigalli, Ilaria, Pepe, Stefano, Settembre, Carmine, Nusco, Edoardo, Auricchio, Alberto, Naldini, Luigi, Ballabio, Andrea, Cosma, Maria Pia

Journal:

Biochemical Journal

Year:

2007

Language:

english

File:

PDF, 483 KB

english, 2007

45

537. New Graph-Based Algorithm for Comprehensive Identification and Tracking Retroviral Integration Sites

Calabria, Andrea, Beretta, Stefano, Merelli, Ivan, Spinozzi, Giulio, Brasca, Stefano, Benedicenti, Fabrizio, Tenderini, Erika, Biffi, Alessandra, Montini, Eugenio

Journal:

Molecular Therapy

Year:

2016

Language:

english

File:

PDF, 369 KB

english, 2016

46

Hematopoietic Stem Cell Gene Therapy for Storage Disease: Current and New Indications

Biffi, Alessandra

Journal:

Molecular Therapy

Year:

2017

Language:

english

File:

PDF, 803 KB

english, 2017

47

Role of the cerebellum in high stages of motor planning hierarchy

Casartelli, Luca, Federici, Alessandra, Cesareo, Ambra, Biffi, Emilia, Valtorta, Giulia, Molteni, Massimo, Ronconi, Luca, Borgatti, Renato

Journal:

Journal of Neurophysiology

Year:

2017

Language:

english

File:

PDF, 603 KB

english, 2017

48

Hematopoietic Gene Therapies for Metabolic and Neurologic Diseases

Biffi, Alessandra

Journal:

Hematology/Oncology Clinics of North America

Year:

2017

Language:

english

File:

PDF, 388 KB

english, 2017

49

Intracerebroventricular delivery of hematopoietic progenitors results in rapid and robust engraftment of microglia-like cells

Capotondo, Alessia, Milazzo, Rita, Garcia-Manteiga, Jose M., Cavalca, Eleonora, Montepeloso, Annita, Garrison, Brian S., Peviani, Marco, Rossi, Derrick J., Biffi, Alessandra

Journal:

Science Advances

Year:

2017

Language:

english

File:

PDF, 7.18 MB

english, 2017

50

Metallothioneins are Neuroprotective Agents in Lysosomal Storage Disorders

Cavalca, Eleonora, Cesani, Martina, Gifford, Jennifer, Sena Esteves, Miguel, Terreni, Maria Rosa, Leoncini, Giuseppe, Peviani, Marco, Biffi, Alessandra

Journal:

Annals of Neurology

Year:

2018

Language:

english

File:

PDF, 1.80 MB

english, 2018